Complications of chronic liver disease these complica tions are also markers for decompensated liver disease and most patients are given a diagnosis of cirrhosis in the presence of these complications decompen sated or unstable liver disease occurs in 2 to 10 of patients with viral hepatitis and in about 25 of patients with alcoholic liver disease the severity of cirrhosis is . Portal hypertension once it develops is the source of potentially devastating complications that include life threatening hemorrhage infection renal failure and coma parenchymal disease can result in coagulopathy as well as altered handling of both endogenous hormones metabolites and exogenous drugs substances. Nonalcoholic fatty liver disease this happens from metabolic syndrome and is caused by conditions such as obesity high cholesterol and triglycerides and high blood pressure other less common causes of cirrhosis may include autoimmune disorders where the bodys infection fighting system immune system attacks healthy tissue. The complications of chronic liver disease can be difficult to manage deranged clotting can be treated with intravenous vitamin k the standard treatment for hepatic encephalopathy is lactulose