Although there is no known animal model for human disease large animal models have demonstrated better suitability for translation to humans for instance swine a species that spontaneously develops atherosclerosis and thrombosis are more closely mimics of the macrovascular related thrombotic complications found in humans. Atherosclerosis is a chronic inflammatory disease that is an underlying basis for most cardiovascular diseases in humans animal models are indispensable for studying the molecular mechanisms that promote atherogenesis and testing therapeutic strategies both large and small animal models have been used to study atherogenesis. The use of animals as experimental models for human diseases is currently seen as an imperative in understanding the causes biology and prevention of diseases animal models over the years have been used extensively in biomedical field since the early 1980s 1 . Because mptp mice are one of the most popular models for screening anti pd agents 23 2630 our results suggest possible use of mirtazapine as a pd therapeutics in clinical patients
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